Tag Archives: pathology

Education Film 38b: Zika Virus and You

The Zika-spreading mosquito Aedes aegypti takes a bloodmeal.
The Zika-spreading mosquito Aedes aegypti takes a bloodmeal. Photo courtesy CDC.

Zika virus is spreading through a hemisphere with plenty of mosquito habitat and no immunity to the disease, and summer is on its way. But what really chills the blood and drives our dread of what was once considered “dengue’s wimpy cousin” is the virus’s horrifying, yet unproven, link to infant microcephaly.

And so, even as epidemiologists struggle to contain and understand the problem, the news swarms with disturbing images and calls for wiping out the offending mosquito vectors. Clearly, if we’re going to get through this, we need to do our homework. Why not start with my article, in which I cut through the buzz to explore …

How Zika Virus Works

Press Release: Open SESAME: Proteins Link Cell Metabolism to Genetics, Offer Possible Cancer Target

Researchers have found a new link between a cell’s basic life functions and its genetic operations. The connection involves a protein complex named SESAME, which uses enzymes responsible for glycolysis to activate proteins that regulate genetic material. Glycolysis is the first stage of cellular metabolism, the chain of biochemical reactions by which cells break down food, build proteins and amino acids, and produce energy.

Although their research involved yeast, the authors say the link may hold true in humans. If a SESAME equivalent in humans is found, it could offer insight to enable novel approaches for cancer risk prediction and treatment. Read my full press release at Stowers Institute for Medical Research:

Protein complex links cellular metabolism to gene expression, offers potential therapeutic target

Maggot Therapy: Seven Debridement’s for Seven Brothers

Maggots (small brown dots) in BioBag (left) , ready for work

During World War I, an American surgeon named William Baer noted that the maggot-ridden wounds he found on some soldiers looked surprisingly healthy, showing fewer signs of inflammation or infection. Baer’s observation was really a rediscovery of the medical value of maggots, a quality known to Napoleon’s Army doctors and probably used by civilizations as far back as the ancient Maya.

Today, doctors use the creepy crawlies to stem infections, speed healing and save money, particularly in cases of chronic wounds like diabetic foot ulcers. Ask your doctor if medical maggots are right for you – but first read

How Maggot Therapy Works

Marine Biology Breakthroughs: I Cover the Waterfront

Photo of coral, goldies and and two divers
Photo by Derek Keats.

In honor of World Oceans Day (June 8), here’s my recent article on some of the remarkable discoveries made by marine biologists over the past few years. From clearing up the murky “lost years” of juvenile turtles to further solidifying our understanding of a jellyfish’s final fate, these delvers of the deep have shrunk what Shakespeare called “the vasty deep” to something a bit more fathomable but no less amazing. Find out more as I take a deep dive into …

10 Recent Breakthroughs in Marine Biology

A Bizarre Bazaar of Food Facts

Smashed buildings and detritus litter a flooded street following the Boston Molasses Disaster of 1919.
The aftermath of the Boston Molasses Disaster of 1919. Photo courtesy Globe Newspaper Co.

Food is both mundane and magical, ephemeral and essential – the ultimate cultural touchstone. Our religions proscribe taboo foods, oblige sacred meals and employ food as a conduit for sacred power. Our myths abound with divine edibles that grant gods immortality, while our folktales counsel against feasting in fairyland lest we trap ourselves forever.

But for all the reverence we pay them, many comestibles arose from humble, bizarre or even disgusting sources, while what we choose, or are compelled, to eat is driven by everything from necessity to neurosis. For better or worse, food scientists, molecular gastronomists and, yes, marketing  firms channel these impulses in profitable (if not always healthy directions). The results are, shall we say, appetizingly bizarre …

10 Weird-but-true Food Facts